Port Pirie Regional Art Gallery is situated on Nukunu Country, in Thalpiri, the Nukunu name for Port Pirie,⁽¹⁾ in the mid-north of South Australia. The gallery sits within sight of the The Wapma Thura — Southern Flinders Ranges National Park co-named for the Nukunu term for "snake people", recognising an important totem.⁽²⁾

The Gallery located in the Cultural Precinct that includes a Library, Visitors Information Centre and Rose Gardens. Gallery facilities include an Artist in Residence Studio, Community Gallery and Workshop, with public programs encompassing outreach to schools, community groups in aged care, disability services and youth support agencies. These programs cater for all ages and diverse community groups.

Port Pirie Regional Art Gallery was established in 1992, exhibiting in the old baggage room of the closed passenger railway station in Port Pirie. The redevelopment of the railway station into the Regional Tourism and Arts Centre in 1994 included a dedicated A-class art gallery.

The gallery air-conditioning was replaced in 2019 with museum-grade climate control to ensure the longevity of the gallery.

The collection focus includes work by local, state and national artists that have been inspired by the Flinders Ranges, such as Hans Heysen and Lawrence Daws. Since opening its doors in 1992, the former Port Pirie Art Prize and the generosity of the community helped to build the city’s growing collection.

The Gallery Program is generously supported by Port Pirie Regional Council, Office for Ageing Well, Regional Arts Australia though Country Arts SA, Arts SA, Australia Council for the Arts, Visions of Australia regional exhibition touring program, Friends of the Gallery Inc. and generous community and philanthropic donations.

Touring Exhibition partners include Country Arts SA, Ace Open, Art Gallery of South Australia, Jam Factory, Regional Art Galleries Association of South Australia, Museums & Galleries of Queensland, Museums & Galleries of NSW, Museums & Galleries of Victoria, ACMI, National Gallery of Australia, National Portrait Gallery, Umbrella Studios, Queensland, Arts Space, Sydney,

The Gallery accepts EOI'S to exhibit all year round. Contact the Gallery Director to discuss your proposal.